Jane Achan, MBChB, MMed, MSc

Lecturer, Department of Paediatrics and Child Health, Makerere University


E-mail Address:  achanj@yahoo.co.uk

 

Jane Achan

Current Main Activities:
Dr. Jane Achan is a Lecturer and Pediatrician at Makerere University and the current President of the Uganda Pediatric Association. Dr. Achan has worked in the field of pediatrics since 1999 and is one of the most experienced Ugandan pediatricians specialized in HIV care, actively involved in research, and has extensive experience in the management of ART and complex HIV cases. She received numerous awards of recognition for her work.

 

Education and Training:
University of London, MSc, Clinical trials, 2008-2012


University of California, San Francisco, Certificate, Designing Clinical Research, 2008


Makerere University, MMed, Pediatrics and Child Health, 2001-2004


Makerere University, MBChB, Medicine and Surgery, 2001-2004

 

Publications:

1. Achan J, Kakuru A, Ikilezi G, Ruel T, Clark TD, Nsanzabana C, Charlebois E, Aweeka F, Dorsey G, Rosenthal PJ, Havlir D, Kamya MR.Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children. N Engl J Med. 2012 Nov 29;367(22):2110-8. doi: 10.1056/NEJMoa1200501.


2. Mpimbaza A, Achan J. Editorial commentary on: Malaria parasitaemia among long distance truck drivers in the Niger delta of Nigeria. Afr Health Sci. 2012 Jun;12(2):89. doi: 10.4314/ahs.v12i2.2. No abstract available.


3. Achan J, Mpimbaza A. Vitamin A as adjunct therapy for cerebral malaria: what is the evidence? Afr Health Sci. 2012 Jun;12(2):87-8. doi: 10.4314/ahs.v12i2.1.


4. Kyabayinze DJ, Achan J, Nakanjako D, Mpeka B, Mawejje H, Mugizi R, Kalyango JN, D'Alessandro U, Talisuna A, Jean-Pierre Vg. Parasite-based malaria diagnosis: are health systems in Uganda equipped enough to implement the policy? BMC Public Health. 2012 Aug 24;12:695. doi: 10.1186/1471-2458-12-695.


5. Young S, Murray K, Mwesigwa J, Natureeba P, Osterbauer B, Achan J, Arinaitwe E, Clark T, Ades V, Plenty A, Charlebois E, Ruel T, Kamya M, Havlir D, Cohan D. Maternal nutritional status predicts adverse birth outcomes among HIV-infected Rural Ugandan women receiving combination antiretroviral therapy. PLoS One. 2012;7(8):e41934. doi: 10.1371/journal.pone.0041934. Epub 2012 Aug 7.


6. Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C, Kamya MR, Wong JK Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts. Clin Infect Dis. 2012 Apr;54(7):1001-9. doi: 10.1093/cid/cir1037. Epub 2012 Feb 4.


7. Ucakacon PS, Achan J, Kutyabami P, Odoi AR, Kalyango NJ. Prescribing practices for malaria in a rural Ugandan hospital: evaluation of a new malaria treatment policy. Afr Health Sci. 2011 Aug;11 Suppl 1:S53-9.


8. Ruel TD, Zanoni BC, Ssewanyana I, Cao H, Havlir DV, Kamya M, Achan J, Charlebois ED, Feeney ME.Sex differences in HIV RNA level and CD4 cell percentage during childhood. Clin Infect Dis. 2011 Sep;53(6):592-9. doi: 10.1093/cid/cir484. Epub 2011 Aug 12.


9. Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK, Baliraine FN, Rosenthal PJ, D'Alessandro U. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. Malar J. 2011 May 24;10:144. doi: 10.1186/1475-2875-10-144. Review.


10. Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ. Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts. Acta Trop. 2012 Mar;121(3):184-95. doi: 10.1016/j.actatropica.2011.03.004. Epub 2011 Mar 21. Review.


11. Achan J, Tibenderana J, Kyabayinze D, Mawejje H, Mugizi R, Mpeka B, Talisuna A, D'Alessandro U. Case management of severe malaria--a forgotten practice: experiences from health facilities in Uganda. PLoS One. 2011 Mar 1;6(3):e17053. doi: 10.1371/journal.pone.0017053.


12. Ruel TD, Kamya MR, Li P, Pasutti W, Charlebois ED, Liegler T, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK, Achan J. Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children. J Acquir Immune Defic Syndr. 2011 Jan 1;56(1):44-50. doi: 10.1097/QAI.0b013e3181fbcbf7.


13. Baliraine FN, Nsobya SL, Achan J, Tibenderana JK, Talisuna AO, Greenhouse B, Rosenthal PJ. Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda. Antimicrob Agents Chemother. 2011 Feb;55(2):615-22. doi: 10.1128/AAC.00954-10. Epub 2010 Nov 15.


14. Charlebois ED, Ruel TD, Gasasira AF, Achan J, Kateera F, Akello C, Cao H, Dorsey G, Rosenthal PJ, Ssewanyana I, Kamya MR, Havlir DV. Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapy. J Acquir Immune Defic Syndr. 2010 Nov;55(3):330-5. doi: 10.1097/QAI.0b013e3181e583da.


15. Gasasira AF, Kamya MR, Ochong EO, Vora N, Achan J, Charlebois E, Ruel T, Kateera F, Meya DN, Havlir D, Rosenthal PJ, Dorsey G. Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance. Malar J. 2010 Jun 23;9:177. doi: 10.1186/1475-2875-9-177.

16. Boivin MJ, Ruel TD, Boal HE, Bangirana P, Cao H, Eller LA, Charlebois E, Havlir DV, Kamya MR, Achan J, Akello C, Wong JK. HIV-subtype A is associated with poorer neuropsychological performance compared with subtype D in antiretroviral therapy-naive Ugandan children. AIDS. 2010 May 15;24(8):1163-70.

17. Newman PM, Wanzira H, Tumwine G, Arinaitwe E, Waldman S, Achan J, Havlir D, Rosenthal PJ, Dorsey G, Clark TD, Cohan D. Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda. Malar J. 2009 Nov 14;8:254. doi: 10.1186/1475-2875-8-254.

18. Achan J, Tibenderana JK, Kyabayinze D, Wabwire Mangen F, Kamya MR, Dorsey G, D'Alessandro U, Rosenthal PJ, Talisuna AO. Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial. BMJ. 2009 Jul 21;339:b2763. doi: 10.1136/bmj.b2763.


19. Yeka A, Achan J, D'Alessandro U, Talisuna AO. Quinine monotherapy for treating uncomplicated malaria in the era of artemisinin-based combination therapy: an appropriate public health policy? Lancet Infect Dis. 2009 Jul;9(7):448-52. doi: 10.1016/S1473-3099(09)70109-4. Review.


20. Ruel T, Ssewanyana I, Achan J, Gasasira A, Kamya MR, Kekitiinwa A, Wong JK, Cao H, Havlir D, Charlebois ED. Dynamics of T cell activation accompanying CD4 recovery in antiretroviral treated HIV-infected Ugandan children. Clin Immunol. 2009 Jun;131(3):410-4. doi: 10.1016/j.clim.2009.01.016. Epub 2009 Mar 19.


21. Ruel TD, Achan J, Gasasira AF, Charlebois ED, Mehbratu T, Rosenthal PJ, Dorsey G, Kamya MR, Kekitiinwa A, Wong J, Havlir DV. HIV RNA suppression among HIV-infected Ugandan children with measles. J Acquir Immune Defic Syndr. 2008 Jun 1;48(2):225-7. doi: 10.1097/QAI.0b013e31816d9c86. No abstract available.


22. Gasasira AF, Kamya MR, Achan J, Mebrahtu T, Kalyango JN, Ruel T, Charlebois E, Staedke SG, Kekitiinwa A, Rosenthal PJ, Havlir D, Dorsey G.High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. Clin Infect Dis. 2008 Apr 1;46(7):985-91. doi: 10.1086/529192.


23. Ssewanyana I, Elrefaei M, Dorsey G, Ruel T, Jones NG, Gasasira A, Kamya M, Nakiwala J, Achan J, Charlebois E, Havlir D, Cao H. Profile of T cell immune responses in HIV-infected children from Uganda. J Infect Dis. 2007 Dec 1;196(11):1667-70. Epub 2007 Oct 25.


24. Achan J, Byarugaba J, Barennes H, Tumwine JK. Rectal versus intravenous quinine for the treatment of childhood cerebral malaria in Kampala, Uganda: a randomized, double-blind clinical trial. Clin Infect Dis. 2007 Dec 1;45(11):1446-52. Epub 2007 Oct 22.


25. Kamya MR, Gasasira AF, Achan J, Mebrahtu T, Ruel T, Kekitiinwa A, Charlebois ED, Rosenthal PJ, Havlir D, Dorsey G. Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children. AIDS. 2007 Oct 1;21(15):2059-66.