Grant Dorsey, M.D., Ph.D.

Associate Professor in Residence, School of Medicine, Department of Infectious Disesases, UCSF


E-mail Address:  gdorsey@medsfgh.ucsf.edu

 

grant

Research Interests:
Clinical and molecular studies of antimalarial drug resistance and the epidemiology of malaria; Interactions between HIV and malaria

 

Education and Training:
University of California, Berkeley PhD, Epidemiology 2001-2004


University of California, San Francisco Fellowship, Infectious Diseases 1998-2002

University of California, Berkeley MPH, Epidemiology 1996-1997

University of California, San Francisco Residency, Medicine 1993-1996

Southwestern Medical Center, Dallas, Texas MD, Medicine 1989-1993

University of Texas at Austin BA, Microbiology 1985-1989

 

Publications:

1. Keh CE, Jha AR, Nzarubara B, Lanar DE, Dutta S, Theisen M, Rosenthal PJ, Dorsey G, Nixon DF, Greenhouse B. Associations between Antibodies to a Panel of Plasmodium falciparum Specific Antigens and Response to Sub-Optimal Antimalarial Therapy in Kampala, Uganda. PLoS One. 2012;7(12):e52571. doi: 10.1371/journal.pone.0052571. Epub 2012 Dec 19. PMID: 23285095


2. Jagannathan P, Muhindo MK, Kakuru A, Arinaitwe E, Greenhouse B, Tappero J, Rosenthal PJ, Kaharuza F, Kamya MR, Dorsey G. Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda. Malar J. 2012 Dec 28;11(1):435. [Epub ahead of


3. Osterbauer B, Kapisi J, Bigira V, Mwangwa F, Kinara S, Kamya MR, Dorsey G. Factors associated with malaria parasitaemia, malnutrition, and anaemia among HIV-exposed and unexposed Ugandan infants: a cross-sectional survey. Malar J. 2012 Dec 27;11(1):432. [Epub ahead of print] PMID: 23270614


4. Achan J, Kakuru A, Ikilezi G, Ruel T, Clark TD, Nsanzabana C, Charlebois E, Aweeka F, Dorsey G, Rosenthal PJ, Havlir D, Kamya MR. Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children. N Engl J Med. 2012 Nov 29;367(22):2110-8. doi: 10.1056/NEJMoa1200501. PMID: 23190222


5. Kigozi R, Baxi SM, Gasasira A, Sserwanga A, Kakeeto S, Nasr S, Rubahika D, Dissanayake G, Kamya MR, Filler S, Dorsey G. Indoor residual spraying of insecticide and malaria morbidity in a high transmission intensity area of Uganda. PLoS One. 2012;7(8):e42857. doi: 10.1371/journal.pone.0042857. Epub 2012 Aug 6. PMID: 22880123


6. Francis D, Gasasira A, Kigozi R, Kigozi S, Nasr S, Kamya MR, Dorsey G. Health facility-based malaria surveillance: the effects of age, area of residence and diagnostics on test positivity rates. Malar J. 2012 Jul 7;11:229. doi: 10.1186/1475-2875-11-229. PMID: 22770511


7. Arinaitwe E, Gasasira A, Verret W, Homsy J, Wanzira H, Kakuru A, Sandison TG, Young S, Tappero JW, Kamya MR, Dorsey G. The association between malnutrition and the incidence of malaria among young HIV-infected and -uninfected Ugandan children: a prospective study. Malar J. 2012 Mar 27;11:90. doi: 10.1186/1475-2875-11-90. PMID: 22453048


8. Namagembe A, Ssekabira U, Weaver MR, Blum N, Burnett S, Dorsey G, Sebuyira LM, Ojaku A, Schneider G, Willis K, Yeka A. Improved clinical and laboratory skills after team-based, malaria case management training of health care professionals in Uganda. Malar J. 2012 Feb 13;11:44. doi: 10.1186/1475-2875-11-44. PMID: 22330281


9. Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C, Kamya MR, Wong JK. Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts. Clin Infect Dis. 2012 Apr;54(7):1001-9. doi: 10.1093/cid/cir1037. Epub 2012 Feb 4. PMID: 22308272


10. Kay J, Wanzira H, Sandison T, Kakuru A, Bigira V, Kamya M, Homsy J, Tappero JW, Havlir D, Dorsey G, Ruel T. Virologic suppression in nevirapine-exposed HIV-infected infants initiating antiretroviral therapy in rural Uganda. J Trop Pediatr. 2012 Jun;58(3):194-9. doi: 10.1093/tropej/fmr071. Epub 2011 Sep 19. PMID: 21930666


11. Talisuna A, Adibaku S, Dorsey G, Kamya MR, Rosenthal PJ.Malaria in Uganda: challenges to control on the long road to elimination. II. The path forward. Acta Trop. 2012 Mar;121(3):196-201. doi: 10.1016/j.actatropica.2011.06.013. Epub 2011 Jul 2. PMID: 21756863


12. Greenhouse B, Ho B, Hubbard A, Njama-Meya D, Narum DL, Lanar DE, Dutta S, Rosenthal PJ, Dorsey G, John CC. Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection


13. Kiggundu M, Nsobya SL, Kamya MR, Filler S, Nasr S, Dorsey G, Yeka A. Evaluation of a comprehensive refresher training program in malaria microscopy covering four districts of Uganda. Am J Trop Med Hyg. 2011 May;84(5):820-4. doi: 10.4269/ajtmh.2011.10-0597. PMID: 21540396


14. Sandison TG, Homsy J, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Kalamya J, Vora N, Kublin J, Kamya MR, Dorsey G, Tappero JW. A randomized clinical trial of the protective efficacy of trimethoprim-sulfamethoxazole prophylaxis in HIV-exposed children in rural Uganda. British Medical Journal 2011;342:d1617. PMCID: PMC3068910


15. Vora N, Homsy J, Kakuru A, Arinaitwe E, Wanzira H, Sandison TG, MD, Bigira V, Kamya MR, Tappero JW, Dorsey G. Breastfeeding and the Risk of Malaria in Children Born to HIV-Infected and Uninfected Mothers in Rural Uganda. JAIDS 2010;55(2):253-61. PMID: 20683193


16. Arinaitwe E, Sandison TG, Wanzira H, Kakuru A, Homsy J, Kalamya J, Kamya MR, Vora N, Greenhouse B, Rosenthal PJ, Tappero J, Dorsey G. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: longitudinal randomized trial in HIV-infected and uninfected children. Clinical Infectious Diseases 2009;49(11):1629-37. PMID: 19877969


17. Greenhouse B, Slater M, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Clark TD, Staedke SG, Kamya MR, Hubbard A, Rosenthal PJ, Dorsey G. Decreasing efficacy of antimalarial combination therapy in Uganda explained by decreasing host immunity rather than increasing drug resistance. Journal of Infectious Diseases 2009;199(5):758-65. PMCID: PMC2733854


18. Staedke SG, Mwebaza N, Kamya MR, Clark TD, Dorsey G, Rosenthal PJ, Whitty CJM. Evaluation of home management of malaria with artemether-lumefantrine in urban Ugandan children: a randomised trial. Lancet 2009;373(9675):1623-31. PMID: 19362361


19. German P, Parikh S, Lawrence J, Dorsey G, Rosenthal PJ, Havlir D, Charlebois E, Hanpithakpong W, Lindegardh N, Aweeka FT. Lopinavir/Ritonavir Affects Pharmacokinetic Exposure of Artemether /Lumefantrine in HIV Uninfected Healthy Volunteers. JAIDS 2009;51(4):424-29. PMID: 19506482


20. Yeka A, Dorsey G, Kamya MR, Talisuna A, Lugemwa M, Rwakimari JB, Staedke SG, Rosenthal PJ, Wabwire-Mangen F, Bukirwa H. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda. PLoS One 2008;3(6):e2390. PMCID: PMC2405936


21. Clark TD, Greenhouse B, Njama-Meya D; Nzarubara B, Maiteki-Sebuguzi C, Sarah G Staedke SG, Seto E, Kamya MR, Rosenthal PJ, Dorsey G. Factors determining heterogeneity of malaria incidence in children in Kampala, Uganda. Journal of Infectious Diseases 2008;198(3):393-400. PMID: 18522503


22. Dorsey G, Staedke S, Clark TD, Njama-Meya D, , Nzarubara B, Maiteki-Sebuguzi C, Dokomajilar C, Kamya MR, Rosenthal PJ. Combination therapy for the treatment of uncomplicated falciparum malaria: a longitudinal randomized clinical trial in a cohort of Ugandan children. JAMA 2007;297(20):2210-9. PMID:17519410 [PubMed - indexed for MEDLINE]


23. Kamya MR, Gasasira AF, Achan J, Mebrahtu T, Ruel T, Kekitiinwa A, Charlebois ED, Rosenthal PJ, Havlir D, Dorsey G. The effect of trimethoprim-sulfamethoxazole prophylaxis and insecticide treated bednets on the risk of malaria among HIV infected Ugandan children. AIDS 2007;21(15):2059-66. PMID: 20573194 PMCID: PMC2903607


24. Staedke SG, Mpimbaza A, Kamya MR, Nzarubara BK, Dorsey G, Rosenthal PJ. Combination therapies for uncomplicated falciparum malaria in Kampala, Uganda: a randomized clinical trial. Lancet 2004;364(9449):1950-7.


25. Staedke S, Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Charlebois ED, Rosenthal PJ. Comparative efficacy of sulfadoxine-pyrimethamine, amodiaquine, and combination therapy for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Lancet 2001;358:368-74