Staff Members

Adithya Cattamanchi

Adoke Yeka

Diane Havlir

Faith Mukoya

Florence Nankya

Geoff Lavoy

Grant Dorsey

Heidi Hopkins

Joseph Kasule

Kalema Nelson

Laurence Huang

Levi Mugenyi

Luke Davis

Norah Mwebaza

Patrick Byanyima

Rachel Kyeyune

Sarah Staedke

Saskia den Boon

Susan Nayiga

Tamara Clark

Theodore Ruel

Grant Dorsey, MD, PhD

Assistant Professor

Affiliation: UCSF

E-mail Address:  gdorsey@medsfgh.ucsf.edu

 
grant

Professional Interests:
Malaria, drug resistance, HIV/malaria interactions, epidemiology.

 

Current Main Activities:
Principal investigator: Children with HIV and malaria project (CHAMP), Longitudinal comparison of combination antimalarial therapy (U01), Tororo Child Cohort (TCC) study, Malaria surveillance project (UMSP); Molecular epidemiology and markers of drug resistance (UCSF).

 

Education and Training:
University of California, San Francisco Residency, Medicine1993-1996
University of Texas at Austin BA, Microbiology 1985-1989
Southwestern Medical Center, Dallas, Texas MD, Medicine1989-1993
University of California, Berkeley MPH, Epidemiology 1996-1997
University of California, San Francisco Fellowship, Infectious Diseases 1998-2002
University of California, Berkeley PhD, Epidemiology 2001-2004

 

Publications:

  • Dorsey G, Staedke S, Clark TD, Njama-Meya D, , Nzarubara B, Maiteki-Sebuguzi C, Dokomajilar C, Kamya MR, Rosenthal PJ. Combination therapy for the treatment of uncomplicated falciparum malaria: a longitudinal randomized clinical trial in a cohort of Ugandan children. JAMA 2007;297(20):2210-9.

  • Kamya MR, Gasasira AF, Achan J, Mebrahtu T, Ruel T, Kekitiinwa A, Charlebois ED, Rosenthal  PJ, Havlir D, Dorsey G. The effect of trimethoprim-sulfamethoxazole prophylaxis and insecticide treated bednets on the risk of malaria among HIV infected Ugandan children. AIDS 2007;21(15):2059-66.

  • Zongo I, Dorsey G, Rouamba N, Tinto H, Dokomajilar C, Guiguemde RT, Rosenthal PJ, Ouedraogo JB. Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Burkina Faso: a randomized controlled trial. Lancet 2007;369:491-98.

  • Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, Machekano R, Dokomajilar C, Rosenthal PJ, Dorsey G. Geographic differences in antimalarial drug efficacy explained by differences in endemicity and not molecular markers of drug resistance. Journal of Infectious Diseases 2006;193(7):978-86.

  • Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya S, Kilian A, Slater M, Reingold A, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. Artemisinin versus non-artemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. PLoS Medicine 2005;2(7):e190.

  • Dorsey G, Gandhi M, Oyugi JW, Rosenthal PJ.  Difficulties in the prevention, diagnosis, and treatment of imported malaria: Review of 121 cases from San Francisco. Archives of Internal Medicine 2000;160(16):2505-10.

  • Dorsey G, Borneo H, Sun S, Wells J, Steele L, Howland K, Perdreau-Remington F, Bangsberg D. A heterogeneous outbreak of Enterobacter cloacae and Serratia marcescens in a surgical ICU.  Infection Control and Hospital Epidemiology 2000; 21(7):465-69.

  • Dorsey G, Kamya MR, Ndezi G, Babiryi J, Rosenthal PJ.  Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda.  American Journal of Tropical Medicine and Hygiene 2000;62:686-92.

  • Dorsey G, Kamya MR, Singh AJ, Rosenthal PJ. Polymorphisms in Plasmodium falciparum pfcrt and pfmdr-1 genes and in vivo chloroquine resistance in Kampala, Uganda.  Journal of Infectious Diseases 2001;183:1417-20.

  • Kamya M, Dorsey G, Gasasira A, Ndeezi G, Babirya J, Steadke S, Rosenthal PJ.  The comparative efficacy of chloroquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Kampala, Uganda.  Transaction of the Royal Society of Tropical Medicine and Hygiene 2001; 95:1-6.

  • Steadke S, Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Charlebois ED, Rosenthal PJ. Comparative efficacy of sulfadoxine-pyrimethamine, amodiaquine, and combination therapy for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Lancet 2001;358:368-74.

  • Dorsey G, Njama D, Kamya MR, Cattamanchi A, Kyabayinze D, Staedke SG, Gasasira A, Rosenthal PJ.  Sulfadoxine/pyrimethamine alone or in combination with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomized trial. Lancet 2002;360:2031-38.

  • Gasasira AF, Dorsey G, Nzarubara B, Staedke SG, Nassali A, Rosenthal PJ, Kamya MR. Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. American Journal of Tropical Medicine and Hygiene 2003; 68:127-32.

  • Cattamanchi A, Kyabayinze D, Hubbard A, Rosenthal PJ, Dorsey G. Distinguishingrecrudescence from reinfection in a longitudinal antimalarial drug efficacy study: Comparison of results based on genotyping of MSP-1, MSP-2, and GLURP. American Journal of Tropical Medicine and Hygiene 2003; 68:133-39.

  • Njama D, Dorsey G, Guwatudde D, Kigonya K, Greenhouse B, Musisi S, Kamya MR. Urban malaria: Primary caregivers’ knowledge, attitudes, practices and predictors of malaria incidence in a cohort of Ugandan children. Tropical Medicine and International Health 2003; 8(8):685-92.

  • Staedke SG, Nottingham EW, Cox J, Kamya MR, Rosenthal PJ, Dorsey G. Proximity of mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children. American Journal of Tropical Medicine and Hygiene 2003;69:244-46.

  • Kyabayinze D, Cattamanchi A, Kamya MR, Rosenthal PJ and Dorsey G. Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria. American Journal of Tropical Medicine and Hygiene 2003;69:247-52.

  • Dorsey G, Vlahos J, Kamya MR, Staedke SG, Rosenthal PJ. Prevention of increasing rates of treatment failure by  combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria. Journal of Infectious Diseases 2003;188(8):1231-8.

  • Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR, Rosenthal PJ, Dorsey  G. Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children. Journal of Infectious Diseases 2004;189(12):220-6.

  • Staedke SG, Sendagire H, Lamola S, Kamya MR, Dorsey G, Rosenthal PJ. Relationship between age, molecular markers, and response to sulfadoxine-pyrimethamine treatment in Kampala, Uganda. Tropical Medicine and International Health 2004;9(5):624-9.

  • Njama-Meya  D, Kamya MR, Rosenthal PJ, Dorsey G. Asymptomatic parasitemia as a risk factor for symptomatic malaria in a cohort of Ugandan children. Tropical Medicine and International Health 2004;9(8):862-8.

  • Dorsey G, Gasasira AF, Machekano R, Kamya MR, Staedke SG, Hubbard A. The impact of age, temperature, and parasite density on treatment outcomes from antimalarial clinical trials in Kampala, Uganda. American Journal of Tropical Medicine and Hygiene 2004;71(5):531-6.

  • Staedke SG, Mpimbaza A, Kamya MR, Nzarubara BK, Dorsey G, Rosenthal PJ. Combination therapies for uncomplicated falciparum malaria in Kampala, Uganda: a randomized clinical trial. Lancet 2004;364(9449):1950-7.

  • Dorsey G, Dokomajilar C, Kiggundu M, Staedke SG, Kamya MR, Rosenthal PJ. Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda. American Journal of Tropical Medicine and Hygiene 2004;71(6):758-63.

  • Parikh S, Dorsey G, Rosenthal PJ. Host polymorphisms and the incidence of malaria in Ugandan children. American Journal of Tropical Medicine and Hygiene 2004;71(6):750-3.

  • Bakyaita N, Dorsey G, Yeka A, Banek K, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya S, Langi P, Kilian A, Reingold A, Rosenthal PJ, Wabwire-Mangen F. Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multi-site trial to guide national policy in Uganda. American Journal of Tropical Medicine and Hygiene 2005;72(5):573-80.

  • Slater M, Kiggundu M, Dokomajilar C, Kamya MR, Bakyaita N, Talisuna A, Rosenthal PJ, Dorsey G. Distinguishing recrudescence from new infections in antimalarial clinical trials: interpretation of genotyping results has a major impact on estimates of drug efficacy. American Journal of Tropical Medicine and Hygiene 2005;73(2):256-62.

  • Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya S, Kilian A, Slater M, Reingold A, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. Artemisinin versus non-artemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. PLoS Medicine 2005;2(7):e190.

  • Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Lankoande M, Ouedraogo JB, Rosenthal PJ. Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso. American Journal of Tropical Medicine and Hygiene 2005;73(5):826-32.

  • Eggena M, Hopkins H, Barugahare B, Okello M, Mugyenyi P, Rosenthal  PJ, Huyen Cao H, Dorsey G. CD4 T cell activation is a predictor for treatment failure in Ugandans with falciparum malaria. American Journal of Tropical Medicine and Hygiene 2006;74(1):41-43.

  • Hwang J, Bitarakwate E, Pai M, Reingold A, Rosenthal PJ, Dorsey G. Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review. Tropical Medicine and International Health 2006;11(6):789-99.

  • Kamya MR, Gasasira AF, Yeka A, Bakyaita N, Nsobya SL, Francis D, Rosenthal PJ, Dorsey G, Havlir D. Effect of HIV infection on malaria treatment outcome in Uganda: A population based study. Journal of Infectious Diseases 2006;193(1):9-15.

  • Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, Machekano R, Dokomajilar C, Rosenthal PJ, Dorsey G. Geographic differences in antimalarial drug efficacy explained by differences in endemicity and not molecular markers of drug resistance. Journal of Infectious Diseases 2006;193(7):978-86.

  • Lee SA, Yeka A, Nsobya SL, Dokomajilar C, Rosenthal PJ, Talisuna A, Dorsey G. Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at seven sites in Uganda. Journal of Infectious Diseases 2006;193(8):1160-63.

  • Myrick A, Leemann E, Dokomajilar C, Hopkins H, Dorsey G, Kamya MR, Rosenthal PJ. The dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda. American Journal of Tropical Medicine and Hygiene 2006;74(5):758-61.

  • Kemble SK, Davis JC, Nalugwa T, Njama-Meya D, Hopkins H, Dorsey G, Staedke S. Prevention and treatment strategies used for the community management of childhood fever in Kampala, Uganda. American Journal of Tropical Medicine and Hygiene 2006;74(6):999-1007.

  • Malamba S, Mermin J, Reingold A, Lule J, Downing R, Ransom R, Kigozi A, Hunt BM, Hubbard A, Rosenthal PJ, Dorsey G. Effect of cotrimoxazole prophylaxis taken by HIV-infected persons on the selection of sulfadoxine-pyrimethamine resistant malaria parasites among HIV-uninfected family members. American Journal of Tropical Medicine and Hygiene 2006;75(3):375-80.

  • Davis JC, Clark TD, Kemble SK, Nalugwa T, Njama-Meya D, Staedke S, Dorsey G. Longitudinal study of urban malaria in a cohort of Ugandan children: Description of study site, census, and recruitment. Malaria Journal 2006;5:18.

  • Bukirwa H, Yeka A, Kamya MR, Talisuna A, Rwakimari JB, Rosenthal PJ, Wabwire-Mangen F, Dorsey G, Staedke S. Amodiaquine plus artesunate versus artemether-lumefantrine for the treatment of uncomplicated malaria in Tororo, Uganda: a randomized controlled trial. PLoS Clinical Trials 2006;1(1):e7.

  • Gasasira A, Dorsey G, Kamya MR, Havlir D, Kiggundu M, Rosenthal PJ, Charlebois E. False positive HIV EIA test results in uncomplicated malaria. Journal of Clinical Microbiology 2006;44(8):3021-24.

  • Dokomajilar C, Lankoande ZM, Dorsey G, Zongo I, Ouedraogo JB, Rosenthal PJ.

  • Molecular polymorphisms and resistance to amodiaquine and sulfadoxine-  

  • pyrimethamine for the treatment of malaria in Burkina Faso. American Journal of Tropical Medicine and Hygiene 2006;75(1):162-5.

  • Dokomajilar C, Nsobya SL, Greenhouse B, Rosenthal PJ, Dorsey G. Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine from a highly endemic area of Uganda. Antimicrobial Agents and Chemotherapeutics 2006;50(5):1893-95.

  • Greenhouse B, Myrick A, Dokomajilar C, Woo JM, Carlson EJ, Rosenthal PJ, Dorsey G. Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections.  American Journal of Tropical Medicine and Hygiene 2006;75(5):836-42.

  • Collins W, Greenhouse, B, Rosenthal PJ, Dorsey G. The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005.
    Malaria Journal 2006;5(1):122.

  • Zongo I, Dorsey G, Rouamba N, Tinto H, Dokomajilar C, Guiguemde RT, Rosenthal PJ, Ouedraogo JB. Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Burkina Faso: a randomized controlled trial. Lancet 2007;369:491-98.

  • German P, Greenhouse B, Coates C, Dorsey G, Rosenthal PJ, Charlebois E, Lindegardh N, Havlir D, Aweeka FT. Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz. Clinical Infectious Diseases 2007;44(6):889-91.

  • Njama-Meya D, Clark TD, Nzarubara B, Staedke S, Kamya MR, Dorsey G. Treatment of malaria restricted to laboratory confirmed cases: a prospective cohort study in Ugandan children. Malaria Journal 2007;6:7.

  • Kamya MR, Gasasira AF, Achan J, Mebrahtu T, Ruel T, Kekitiinwa A, Charlebois ED, Rosenthal  PJ, Havlir D, Dorsey G. The effect of trimethoprim-sulfamethoxazole prophylaxis and insecticide treated bednets on the risk of malaria among HIV infected Ugandan children. AIDS 2007;21(15):2059-66.


  • Dorsey G, Staedke S, Clark TD, Njama-Meya D, , Nzarubara B, Maiteki-Sebuguzi C, Dokomajilar C, Kamya MR, Rosenthal PJ. Combination therapy for the treatment of uncomplicated falciparum malaria: a longitudinal randomized clinical trial in a cohort of Ugandan children. JAMA 2007;297(20):2210-9.

  • Kamya MR, Yeka A, Bukirwa H, Lugemwa M, Rwakimari JB, Staedke SG, Talisuna AO, Greenhouse B, Nosten  F, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of uncomplicated falciparum malaria: A randomized clinical trial at a high transmission site in Uganda. PLoS Clinical Trials 2007;2(5):e20.

  • Greenhouse B, Dokomajilar C, Hubbard A, Rosenthal PJ, Dorsey G. Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials. Antimicrobial Agents and Chemotherapeutics 2007;51(9):3096-103.

  • Hopkins H, Kambale W, Kamya M, Staedke S, Dorsey G, Rosenthal P. Comparison of HRP-2 and pLDH-based rapic diagnositic tests for malaria with longitudinal follow-up in Kampala, Uganda. American Journal of Tropical Medicine and Hygiene 2007;76(6):1092-97.

  • WJR. Artesunate and Amodiaquine for the treatment of uncomplicated falciparum malaria: a systematic review and meta-analysis of efficacy and safety data. Submitted for publication.

  • Price RN, Dorsey G, Ashley EA, Karen I. Barnes KI, Baird JK, D’Alessandro U, Guerin P, Laufer MK, Naidoo I, Nosten F, Olliaro P, Plowe CV, Ringwald P, Sibley CH, Stepniewska K, White NJ. Creating a global database for monitoring the clinical efficacy of antimalarial therapy. Malaria Journal 2007;6:119.

  • Ssewanyana I, Elrefaei M, Dorsey G, Ruel T, Jones NG, Gasasira A, Kamya MR, Nakiwala J, Achan J, Charlebois E, Havlir D, Cao H. Profile of T Cell Immune Responses in HIV Infected Children from Uganda. Journal of Infectious Diseases 2007;196:1667-70.

  • Bebell L, Gasasira A, Kiggundu M, Dokomajilar C, Kamya MR, Charlebois E, Havlir D, Rosenthal PJ, Dorsey G. HIV-1 infection in patients referred for malaria blood smears at government health clinics in Uganda. JAIDS 2007;46(5):624-630.

  • Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Sere Y, Rosenthal PJ, Ouedraogo JB. Randomized comparison of amodiaquine-sulfadoxine/pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Burkina Faso. Clinical Infectious Diseases 2007;45:1453-61.

  • Nsobya SL, Dokomajilar C, Joloba M, Dorsey G, Rosenthal PJ. Resistance-mediating Plasmodium falciparum pfcrt and pfmdr-1 alleles after treatment with artesunate-amodiaquine in Uganda. Antimicrobial Agents and Chemotherapeutics 2007;51(8):3023-5.

  • Machekano RN, Dorsey G, Hubbard A. Efficacy studies of malaria treatments in Africa: efficient estimation with missing indicators of failure. Stat Methods Med Res 2007; in press.

  • Hopkins H, Kambale W, Bebell L, Dokomajilar C, Rosenthal PJ, Dorsey G. Rapid diagnostic tests for malaria at sites of varied transmission intensity in Uganda. . Journal of Infectious Diseases 2007; in press.

  • Ssewanyana I, Pietras C, Baker CAR, Nghania F, Jones NG, Rosenthal PJ, Dorsey G, Cao H. Pattern of malaria-specific T-cell responses in a cohort of Ugandan children. Journal of Tropical Pediatrics 2007; in press.