Sam Nsobya, PhD

Senior Lecturer, School Biomedical Science , Makererer University


E-mail Address:  samnsobya@muucsf.org

 

Dr. Sam Nsobya

Current Main Activities:
Senior lecturer teaching molecular biology and biomedical laboratory science to under and postgraduate students. Dr Nsobya is also Laboratory Director of Molecular Research Laboratory (Molab),MUUCSF. He has 22 years experience in laboratory science with additional wide –range of expertise in laboratory-based malaria diagnosis namely; in vitro studies of antimalarial drug resistance, genotyping of malaria parasites, and identification of molecular markers of drug resistance. He has research interest in laboratory translation research , molecular studies of antimalarial drug resistance and other laboratory based research.

 

Education and Training:
Makerere University Uganda PhD (Medicine) 2006 - 2010

Makerere University Uganda Msc Molecular Biology 2002 – 2004

University of California San Francisco Certificate (Drug resistance) 2002- 2003

Makerere University Uganda BLT. Biomedical laboratory science 1998 - 2001

Makerere University Uganda Diploma Medical lab Technology 1987-1990

 

Publications:

1. Kiggundu M, Nsobya SL, Kamya MR, Filler S, Nasr S, Dorsey G, Yeka A. Evaluation of a comprehensive refresher training program in malaria microscopy covering four districts of Uganda. Am J Trop Med Hyg. 2011 May;84(5):820-4. doi: 10.4269/ajtmh.2011.10-0597. PMID: 21540396


2. Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ. Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts. Acta Trop. 2012 Mar;121(3):184-95. doi: 10.1016/j.actatropica.2011.03.004. Epub 2011 Mar 21. Review. PMID: 21420377


3. Baliraine FN, Nsobya SL, Achan J, Tibenderana JK, Talisuna AO, Greenhouse B, Rosenthal PJ. Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda. Antimicrob Agents Chemother. 2011 Feb;55(2):615-22. doi: 10.1128/AAC.00954-10. Epub 2010 Nov 15. PMID: 21078941


4. Nsobya SL, Kiggundu M, Nanyunja S, Joloba M, Greenhouse B, Rosenthal PJ. In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda. Antimicrob Agents Chemother. 2010 Mar;54(3):1200-6. doi: 10.1128/AAC.01412-09. Epub 2010 Jan 11. PMID: 20065051


5. Nawaz F, Nsobya SL, Kiggundu M, Joloba M, Rosenthal PJ. Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda. J Infect Dis. 2009 Dec 1;200(11):1650-7. doi: 10.1086/647988. PMID: 19905933


6. Nsobya SL, Kiggundu M, Joloba M, Dorsey G, Rosenthal PJ. Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture. J Infect Dis. 2008 Nov 15;198(10):1554-7. doi: 10.1086/592506. PMID: 18808336


7. Nsobya SL, Dokomajilar C, Joloba M, Dorsey G, Rosenthal PJ. Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Antimicrob Agents Chemother. 2007 Aug;51(8):3023-5. Epub 2007 Jun 11. PMID: 17562798


8. Dokomajilar C, Nsobya SL, Greenhouse B, Rosenthal PJ, Dorsey G.Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Antimicrob Agents Chemother. 2006 May;50(5):1893-5. PMID:16641472


9. Lee SA, Yeka A, Nsobya SL, Dokomajilar C, Rosenthal PJ, Talisuna A, Dorsey G. Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda. J Infect Dis. 2006 Apr 15;193(8):1160-3. Epub 2006 Mar 13. PMID: 16544257


10. Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, Machekano R, Dokomajilar C, Rosenthal PJ, Dorsey G. Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance. J Infect Dis. 2006 Apr 1;193(7):978-86. Epub 2006 Mar 1. PMID: 16518760


11. Kamya MR, Gasasira AF, Yeka A, Bakyaita N, Nsobya SL, Francis D, Rosenthal PJ, Dorsey G, Havlir D. Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study. J Infect Dis. 2006 Jan 1;193(1):9-15. Epub 2005 Nov 18. PMID: 16323126


12. Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya SL, Kilian A, Slater M, Reingold A, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. PLoS Med. 2005 Jul;2(7):e190. Epub 2005 Jul 26. PMID: 16033307


13. Bakyaita N, Dorsey G, Yeka A, Banek K, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya S, Kilian A, Reingold A, Rosenthal PJ, Wabwire-Mangen F. Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda. Am J Trop Med Hyg. 2005 May;72(5):573-80. PMID: 15891132


14. Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR, Rosenthal PJ, Dorsey G. Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children. J Infect Dis. 2004 Jun 15;189(12):2220-6. Epub 2004 May 24. PMID: 15181569