Rachel

Rachel Kyeyune, MBChB Medical Officer, International HIV-Associated Opportunistic Pneumonias (IHOP) Intern Doctor, Mulago National Referral Hospital Research Assistant, RDT study, A Study comparing the Accuracy of Rapid Detection Tests compared to microscopy in the diagnosis of malaria in patients attending the Accidents and Emergency Unit in Mulago. Affiliation: MU-UCSF Research Collaboration E-mail Address: smilin.rasasa@gmail.com
Professional Interests: Clinical research, Infectious Diseases and Emergency medicine Current Main Activities: Assisting the study coordinator with screening and enrollment of patients for the IHOP Study. Primarily responsible for the follow up of IHOP study patients at 1, 8, and 24 weeks as well as linking them to appropriate outpatient services International HIV-associated Opportunistic Pneumonias (IHOP) Study. This is an NIH-funded prospective study of HIV-associated pneumonia conducted in 3 cites representing the current HIV/AIDS epidemic in Africa (Kampala, Uganda), Europe (London, United Kingdom), and USA (San Francisco, CA) and involving 6 independent laboratories at the NIH, the University of California San Francisco, the University of Cincinnati, and the University of North Carolina. The goals of this study are: (1) To determine the frequency and mortality of HIV-associated opportunistic pneumonias in an international, multi-center, longitudinal cohort and to test the hypothesis that PCP is associated with increased mortality. (2) To estimate the sensitivity and specificity of molecular tools for PCP and TB diagnosis and to test the hypotheses that 60-second oropharyngeal washing (OPW, gargle) specimens combined with polymerase chain reaction (PCR) assays are sensitive tests to diagnose PCP and TB. (3) To test the hypothesis that P. jirovecii dihydropteroate synthase (DHPS) gene mutations are associated with an increased morbidity and mortality and to explore potential mechanisms, and (4) To characterize the predominant P. jirovecii Msg-C variant recognized by antibodies at the 3 study sites, to examine systemic (serum) and local (BAL) antibody responses, and to test the hypotheses that the level of antibodies to the predominant variant is correlated with PCP status. The IHOP Study serves as the foundation for complementary research studies, led by MU-UCSF Investigators William Worodria, MBChB, MMed, J. Lucian (Luke) Davis, MD, and Adithya Cattamanchi, MD. Education and Training: Bachelor of Medicine and Bachelor of Surgery (MBChB), Makerere University Medical School, Kampala, Uganda

Rachel Kyeyune, MBChB

Medical Officer, International HIV-Associated Opportunistic Pneumonias (IHOP)

Intern Doctor, Mulago National Referral Hospital

Research Assistant, RDT study, A Study comparing the Accuracy of Rapid Detection Tests compared to microscopy in the diagnosis of malaria in patients attending the Accidents and Emergency Unit in Mulago.

Affiliation: MU-UCSF Research Collaboration

E-mail Address: smilin.rasasa@gmail.com

Professional Interests:
Clinical research, Infectious Diseases and Emergency medicine

Current Main Activities:
Assisting the study coordinator with screening and enrollment of patients for the IHOP Study. Primarily responsible for the follow up of IHOP study patients at 1, 8, and 24 weeks as well as linking them to appropriate outpatient services

International HIV-associated Opportunistic Pneumonias (IHOP) Study. This is an NIH-funded prospective study of HIV-associated pneumonia conducted in 3 cites representing the current HIV/AIDS epidemic in Africa (Kampala, Uganda), Europe (London, United Kingdom), and USA (San Francisco, CA) and involving 6 independent laboratories at the NIH, the University of California San Francisco, the University of Cincinnati, and the University of North Carolina. The goals of this study are: (1) To determine the frequency and mortality of HIV-associated opportunistic pneumonias in an international, multi-center, longitudinal cohort and to test the hypothesis that PCP is associated with increased mortality. (2) To estimate the sensitivity and specificity of molecular tools for PCP and TB diagnosis and to test the hypotheses that 60-second oropharyngeal washing (OPW, gargle) specimens combined with polymerase chain reaction (PCR) assays are sensitive tests to diagnose PCP and TB. (3) To test the hypothesis that P. jirovecii dihydropteroate synthase (DHPS) gene mutations are associated with an increased morbidity and mortality and to explore potential mechanisms, and (4) To characterize the predominant P. jirovecii Msg-C variant recognized by antibodies at the 3 study sites, to examine systemic (serum) and local (BAL) antibody responses, and to test the hypotheses that the level of antibodies to the predominant variant is correlated with PCP status. The IHOP Study serves as the foundation for complementary research studies, led by MU-UCSF Investigators William Worodria, MBChB, MMed, J. Lucian (Luke) Davis, MD, and Adithya Cattamanchi, MD.

Education and Training:
Bachelor of Medicine and Bachelor of Surgery (MBChB), Makerere University Medical School, Kampala, Uganda

MU-UCSF Research Collaboration