William Worodria, MBChB, MMed, PhD

Consultant Physician at Ministry of Health, Uganda


E-mail Address:  worodria@yahoo.com

 

Dr. William Worodria

Current Main Activities:
Co-Principal Investigator, Mulago Inpatient Noninvasive Diagnosis of Pneumonia Study

 

Professional Interests:
Research on pulmonary complications associated with HIV disease (drug related toxicity and the Tuberculosis Immune Reconstitution Inflammatory Syndrome). Care of patients with pulmonary disease. To support capacity building in research of common respiratory diseases

 

Education and Training:
EDCTP Senior Fellowship Clinical Fellowship. Topic: Early clinical and immunological outcomes of patients with HIV/TB co-infections on antiretroviral therapy, 2011-2014

University of Antwerp, Belgium, Doctor of Philosophy (PhD), Tuberculosis, HIV, Theme:The Challenges of Pulmonary Complications in HIV/Tuberculosis Infection in Resource Limited settings. 2012

Makerere University, Kampala, Uganda, Master of Medicine, Internal Medicine, 2000

Makerere University, Kampala, Uganda, Bachelor of Medicine and Surgery (M.B.B.S.), 1993

 

Publications:

1. Blount RJ, Jarlsberg LG, Daly KR, Worodria W, Davis JL, Cattamanchi A, Djawe K, Andama A, Koch J, Walzer PD, Huang L; International HIV-Associated Opportunistic Pneumonias (IHOP) Study. Serologic Responses to Recombinant Pneumocystis jirovecii Major Surface Glycoprotein among Ugandan Patients with Respiratory Symptoms. PLoS One. 2012;7(12):e51545. doi: 10.1371/journal.pone.0051545. Epub 2012 Dec 21. PMID: 23284710


2. Taylor SM, Meshnick SR, Worodria W, Andama A, Cattamanchi A, Davis JL, Yoo SD, Byanyima P, Kaswabuli S, Goodman CD, Huang L; International HIV-associated Opportunistic Pneumonias (IHOP) Study. Low Prevalence of Pneumocystis pneumonia (PCP) but High Prevalence of Pneumocystis dihydropteroate synthase (dhps) Gene Mutations in HIV-Infected Persons in Uganda. PLoS One. 2012;7(11):e49991. doi: 10.1371/journal.pone.0049991. Epub 2012 Nov 16. PMID: 23166805


3. Miremba P, Kalyango JN, Worodria W, Mugerwa H, Nakakawa E, Asiimwe BB. Performance of frontloading for smear microscopy in the diagnosis of pulmonary tuberculosis: a cross-sectional study at a referral hospital in Uganda. PLoS One. 2012;7(10):e48531. doi: 10.1371/journal.pone.0048531. Epub 2012 Oct 29. PMID: 23144768


4. Yoon C, Cattamanchi A, Davis JL, Worodria W, den Boon S, Kalema N, Katagira W, Kaswabuli S, Miller C, Andama A, Albert H, Nabeta P, Gray C, Ayakaka I, Huang L. Impact of Xpert MTB/RIF testing on tuberculosis management and outcomes in hospitalized patients in Uganda. PLoS One. 2012;7(11):e48599. doi: 10.1371/journal.pone.0048599. Epub 2012 Nov 6. PMID: 23139799


5. Nakiyingi L, Bwanika JM, Lukande R, Kirenga B, Mwambu TP, Worodria W, Okot-Nwang M. Destructive rib lesions in an HIV sero-negative male: an unusual presentation of tuberculosis in a high tuberculosis prevalence setting. Trop Doct. 2012 Nov 6. [Epub ahead of print] PMID: 23131749


6. Conesa-Botella A, Goovaerts O, Massinga-Loembé M, Worodria W, Mazakpwe D, Luzinda K, Mayanja-Kizza H, Colebunders R, Kestens L; TB IRIS Study Group. Low prevalence of vitamin D deficiency in Ugandan HIV-infected patients with and without tuberculosis. Int J Tuberc Lung Dis. 2012 Nov;16(11):1517-21. doi: 10.5588/ijtld.11.0146. PMID: 23044447


7. Nakiyingi L, Kateete DP, Ocama P, Worodria W, Sempa JB, Asiimwe BB, Katabazi FA, Katamba A, Huang L, Joloba ML, Mayanja-Kizza H. Evaluation of in-house PCR for diagnosis of smear-negative pulmonary tuberculosis in Kampala, Uganda. BMC Res Notes. 2012 Sep 5;5:487. doi: 10.1186/1756-0500-5-487. PMID: 22947399


8. Kalema N, Boon SD, Cattamanchi A, Davis JL, Andama A, Katagira W, Everett C, Walter N, Byanyima P, Kaswabuli S, Worodria W, Huang L. Oral antimicrobial rinse to reduce mycobacterial culture contamination among tuberculosis suspects in Uganda: a prospective study. PLoS One. 2012;7(7):e38888. doi: 10.1371/journal.pone.0038888. Epub 2012 Jul 12. PMID: 22808020


9. Cattamanchi A, Ssewenyana I, Nabatanzi R, Miller CR, Den Boon S, Davis JL, Andama A, Worodria W, Yoo SD, Cao H, Huang L. Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV-infected patients. PLoS One. 2012;7(6):e39838. doi: 10.1371/journal.pone.0039838. Epub 2012 Jun 26. PMID: 22745833


10. Worodria W, Menten J, Massinga-Loembe M, Mazakpwe D, Bagenda D, Koole O, Mayanja-Kizza H, Kestens L, Mugerwa R, Reiss P, Colebunders R; TB-IRIS Study Group. Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis-HIV coinfection. Antivir Ther. 2012;17(5):841-8. doi: 10.3851/IMP2108. Epub 2012 Apr 27. PMID: 22543224


11. Manabe YC, Worodria W, Cobelens F; PROMPT Study Group. Empirical tuberculosis treatment or improved diagnostics? Int J Tuberc Lung Dis. 2012 Feb;16(2):280; author reply 280-1. doi: 10.5588/ijtld.11.0242. PMID:22236934


12. Taylor SM, Meshnick SR, Worodria W, Andama A, Davis JL, Cattamanchi A, den Boon S, Yoo SD, Goodman CD, Huang L; International HIV-associated Opportunistic Pneumonias (IHOP) Study. Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia. Diagn Microbiol Infect Dis. 2012 Feb;72(2):139-43. doi: 10.1016/j.diagmicrobio.2011.10.009. Epub 2011 Dec 5. PMID: 22153850


13. Worodria W, Anderson J, Cattamanchi A, Davis JL, den Boon S, Andama A, Yoo SD, Joloba M, Huang L, Kato-Maeda M. The role of speciation in positive Lowenstein-Jensen culture isolates from a high tuberculosis burden country. PLoS One. 2011;6(11):e27017. doi: 10.1371/journal.pone.0027017. Epub 2011 Nov 4. PMID: 22073241


14. Kisembo HN, Boon SD, Davis JL, Okello R, Worodria W, Cattamanchi A, Huang L, Kawooya MG. Chest radiographic findings of pulmonary tuberculosis in severely immunocompromised patients with the human immunodeficiency virus. Br J Radiol. 2012 Jun;85(1014):e130-9. doi: 10.1259/bjr/70704099. Epub 2011 Oct 5. PMID: 21976629


15. Conesa-Botella A, Loembé MM, Manabe YC, Worodria W, Mazakpwe D, Luzinda K, Mayanja-Kizza H, Miri M, Mbabazi O, Koole O, Kestens L, Colebunders R; TB IRIS Group. Urinary lipoarabinomannan as predictor for the tuberculosis immune reconstitution inflammatory syndrome. J Acquir Immune Defic Syndr. 2011 Dec 15;58(5):463-8. doi: 10.1097/QAI.0b013e31823801de. PMID: 21963941


16. Worodria W, Massinga-Loembe M, Mazakpwe D, Luzinda K, Menten J, Van Leth F, Mayanja-Kizza H, Kestens L, Mugerwa RD, Reiss P, Colebunders R; TB-IRIS Study Group. Incidence and predictors of mortality and the effect of tuberculosis immune reconstitution inflammatory syndrome in a cohort of TB/HIV patients commencing antiretroviral therapy. J Acquir Immune Defic Syndr. 2011 Sep 1;58(1):32-7. doi: 10.1097/QAI.0b013e3182255dc2. PMID: 21654499


17. Huang L, Cattamanchi A, Davis JL, den Boon S, Kovacs J, Meshnick S, Miller RF, Walzer PD, Worodria W, Masur H; International HIV-associated Opportunistic Pneumonias (IHOP) Study; Lung HIV Study. HIV-associated Pneumocystis pneumonia. Proc Am Thorac Soc. 2011 Jun;8(3):294-300. doi: 10.1513/pats.201009-062WR. Review. PMID: 21653531


18. Yoo SD, Cattamanchi A, Den Boon S, Worodria W, Kisembo H, Huang L, Davis JL. Clinical significance of normal chest radiographs among HIV-seropositive patients with suspected tuberculosis in Uganda. Respirology. 2011 Jul;16(5):836-41. doi: 10.1111/j.1440-1843.2011.01981.x. PMID: 21518124


19. Boehme CC, Nicol MP, Nabeta P, Michael JS, Gotuzzo E, Tahirli R, Gler MT, Blakemore R, Worodria W, Gray C, Huang L, Caceres T, Mehdiyev R, Raymond L, Whitelaw A, Sagadevan K, Alexander H, Albert H, Cobelens F, Cox H, Alland D, Perkins MD. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. Lancet. 2011 Apr 30;377(9776):1495-505. doi: 10.1016/S0140-6736(11)60438-8. Epub 2011 Apr 18. PMID: 21507477


20. Davis JL, Huang L, Worodria W, Masur H, Cattamanchi A, Huber C, Miller C, Conville PS, Murray P, Kovacs JA. Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV-prevalence setting: a prospective cohort study. PLoS One. 2011 Jan 27;6(1):e16321. doi: 10.1371/journal.pone.0016321. PMID: 21298001