PI: F. Aweeka; Co-investigator: S. Parikh, M. Kamya, et al
Start Date: June 2007, End Date: Dec, 2008
Funded by: CFAR, Drug Research Unit
This study in children with malaria investigated the pharmacology of artemether/lumefantrine and artesunate/amodiaquine in HIV un-infected children in Kampala, Uganda. It is expected that children will exhibit distinct differences in their pharmacokinetics compared to adults due to maturational effects in drug metabolism. Children (aged 5-13) were enrolled in the study. We evaluated the pharmacokinetics in Ugandan children aged 5-13 years with uncomplicated malaria treated with AL (n=20) or AQ/AS (n=21), with intensive sampling over 7 days following the last dose of 3 day regimens. Comparison to prior adult data suggests that LR exposure is lower in children and that AQ/DEAQ exposure is similar in children and adults. For the artemisinin drugs, differences between exposure in children and adults vary depending on which artemisinin is administered. PK distinctions between children and adults should be considered to optimize dosing strategies for these widely utilized ACT regimens. This work has been previously presented and a paper is currently in press.
1) Mwesigwa J*, Parikh S*, McGee B, German P, Drysdale T, Kalyango J, Clark T, Dorsey G, Lindegardh N, Annerberg A, Rosenthal P, Kamya M, Aweeka F. Pharmacokinetics of artemether-lumefantrine and artesunate/amodiaquine in children in Kampala, Uganda, (Antimicrob Ag Chemother, In Press, 2009). (*both contributed equally)
2) Parikh S, Mwesigwa J, McGee B, German P, Drysdale T, Kalyango J, Clark T, Dorsey G, Lindegardh N, Annerberg A, Rosenthal P, Kamya M, Aweeeka F. Pharmacokinetics of antimalarial drugs, artemether/lumefantrine and artesunate and amodiaquine in HIV uninfected children in Kampala, Uganda. Oral Presentation at American Society of Tropical Health and Hygiene; December, 2008, New Orleans, LA
Other: Pharmacokinetics of antimalarial drugs, artemether/lumefantrine and artesunate and amodiaquine in HIV uninfected children in Kampala, Uganda. Presentation by F. Aweeka. International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT), December, 2008, Baltimore, Md.